SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION

  • A. Hakan AKTAŞ Süleyman Demirel University, Faculty of Science and Arts, Chemistry Department
  • Ümit UÇAR Ms Student
Keywords: rosuvastatin, ezetimibe, spectrometry, multivariate calibration

Abstract

Two multivariate calibration-prediction techniques, principal component analysis (PCR) and partial least squares (PLS) were applied to the spectrometric multicomponent analysis of the drug containing rosuvastatin (ROS) and ezetimibe (EZE) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of ROS and EZE were used to check the prediction ability of the PCR and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.

Downloads

Download data is not yet available.
Published
2018-05-10
How to Cite
AKTAŞ, A. H., & UÇAR, Ümit. (2018). SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION. JOURNAL OF SCIENTIFIC PERSPECTIVES, 2(2), 1-12. https://doi.org/10.26900/jsp2018.8
Section
Basic Science and Engineering