VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION

Keywords: naproxen, voltammetric method, differential pulse voltammetry, cyclic voltammetry, high performance liquid chromatography, ultra-trace graphite electrode, commercial drug tablets

Abstract

In this work, the electrochemical oxidation of naproxen (NAP) was studied at an ultra-trace graphite electrode (UTGE). The cyclic voltammetry (CV) technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer (pH 4.50) was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry (DPV) technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection (LOD) and quantification (LOQ) were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography (HPLC) method. These two methods were compared in terms of accuracy, precision and recovery studies.

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Author Biographies

Selehattin YILMAZ, Çanakkale Onsekiz Mart University/Turkey

** Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: seletyilmaz@hotmail.com

ORCID ID: https://orcid.org/0000-0003-4607-3523

Suzan YANIK, Çanakkale Onsekiz Mart University/Turkey

* Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: suzan.yanik@gmail.com

ORCID ID: https://orcid.org/0000-0002-0532-4149

Gulsen SAGLIKOGLU, Çanakkale Onsekiz Mart University/Turkey

*** Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: gulsensaglikoglu@hotmail.com

ORCID ID: https://orcid.org/0000-0002-3407-9787

Murat SADIKOGLU, Çanakkale Onsekiz Mart University/Turkey

**** Department of Science Education, Faculty of Education, University of Tokat Gaziosmanpasa, TURKEY, e-mail: murat.sadikoglu@yahoo.com

ORCID ID: https://orcid.org/0000-0002-6701-6838

Ozlem TONGUC YAYINTAS, Çanakkale Onsekiz Mart University/Turkey

***** Canakkale Onsekiz Mart University, School of Applied Sciences, Department of Fisheries Technology, TURKEY, e-mail: ozlemyayintas@hotmail.com

ORCID ID: https://orcid.org/0000-0002-3554-1881

References

[1] BOYNTON C.S., DICK C.F., MAYOR G.H., 1988, NSAID: An overview, J. Clint. Pharmacology, 28: 512
[2] KAYNAK M.S., ŞAHİN S.A., 2008, A new hplc approach for determination of in-vitro solubility of naproxen sodium, J, Hacettepe Univ. J. The Faculty of Pharm. 28, 49
[3] ARESTA A., PALMISANO F., ZAMBONIN C.G., 2005, Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography ,J. Pharm. Biomed. Anal. 39, 643
[4] JAIN N.A., LOHIYA R.T., UMEKAR M.J., 2011, Spectrophotometric determination of naproxen and esomerprazole in a laboratory mixture by simultaneous equation, absorption correction, absorption ratio and area under curve methods, Int. J. Pharma Sci. and Research. 2, 130 (ISSN: 0975-9492)
[5] YILMAZ B., ASCI A., ERDEM A.F., 2014, HPLC method for naproxen determination in human plasma and its application to a pharmacokinetic Study in Turkey J. Chromatogr. Sci. 52, 584
[6] TSVETKOVA B., 2015, RP-HPLC method for determination of naproxen in pharmaceutical dosage form, Pharmacia. 62, 15
[7] UYSAL Ü.D., TUNCEL M., 2004, Determination of naproxen in tablets by using first derivative potentiometry, Turkish J. Pharm. Sci. 1, 217
[8] DAMIANI P., BEARZOTTI M., CABEZÓN M.A., 2002, Spectrofluorometric determination of naproxen in tablets, J. Pharm. Biomed. Anal. 29, 229
[9] SARHANGZADEH K., 2015, Application of multi wall carbon nanotube–graphene hybrid for voltammetric determination of naproxen, J. Iran Chem. Soc. 12, 2133
[10] STEFANO J.S., LIMA A.P., MONTES R.H.O., RICHTER E.M., MUÑOZ R.A.A., 2012, Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection, Braz. Chem. Soc. 23, 1834
[11] SOLTANI N., TAVAKKOLI N., MOSAVIMANESH Z.S., DAVAR F., 2018, Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles,C.R. Chimie, 21, 54
[12] ADHOUM N., MONSER L., TOUMI M., BOUJLEL K., 2003, Determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode, Anal. Chim. Acta, 495, 69
[13] SURYANARAYANAN V., ZHANG, YOSHIHARA Y. S., SHIRAKASHI T., 2005, Voltammetric assay of naproxen in pharmaceutical formulations using boron-doped diamond electrode, Electroanalysis, 17, 925
[14] TASHKHOURIAN J., HEMMATEENEJAD B., BEIGIZADEH H., HOSSEINI-SARVARI M., RAZMI Z., 2014, ZnO nanoparticles and multiwalled carbon nanotubes modified carbon paste electrode for determination of naproxen using electrochemical techniques, J. Electroanal. Chem. 714, 103
[15] BEITOLLAHI H., YOONESFAR R., 2016, Fabrication of a novel electrochemical nanosensor for voltammetric determination of naproxen, Anal. Bioanal. Electrochem. 8, 29
[16] AGUILAR-LIRA G.Y., IVAREZ ROMERO G.A., ROJAS-HERNNDEZ A., PEZ-HERNNDEZ M.E., RODRGUEZ-VILA J.A., ROMERO-ROMO M.A., 2014, Voltammetric analysis of naproxen in graphite electrodes and its determination in pharmaceutical samples, Electroanalysis. 26, 1573
[17] SADIKOGLU M., YILMAZ S., KURT I., SELVI B., SARI H., ERDURAN N., USTA E., SAGLIKOGLU G., 2016, Electrocatalytic oxidation of hydrazine on poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode, Russian J. Electrochem. 52, 603.
[18] CAN S., YILMAZ S., SAGLIKOGLU G., SADIKOGLU M., MENEK N., 2015, Electrocatalytic oxidation of acyclovir on poly (p-aminobenzene sulfonic acid) film modified glassy carbon electrode, Electroanalysis. 27, 2431
[19] YILMAZ S., 2016, Electroanalytical chemistry with example of applied, Gazi book house., Ankara, Turkey, 33.
[20] SKOOG D.A., WEST D.M., HOLLER F.J., CROUCH S.R. 2000, Fundamentals of Analytical Chemistry, Bilim Kitap Kirtasiye Ltd. Sti., Ankara, 158.
Published
2019-10-29
How to Cite
YILMAZ, S., YANIK, S., SAGLIKOGLU, G., SADIKOGLU, M., & TONGUC YAYINTAS, O. (2019). VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION. JOURNAL OF SCIENTIFIC PERSPECTIVES, 3(4), 299-310. https://doi.org/10.26900/jsp.3.031
Section
Basic Science and Engineering